Reperfusion injury

Reperfusion injury, sometimes called ischemia-reperfusion injury (IRI) or reoxygenation injury, is the <a href="/facts/Tissue_(biology)/H7CpML7A">tissue</a> damage caused when <a href="/facts/Blood/03zEulkj">blood</a> supply returns to tissue (re- + <a href="/facts/Perfusion/EFVLNUTg">perfusion</a>) after a period of <a href="/facts/Ischemia/ySL9xbCl">ischemia</a> or lack of oxygen (anoxia or <a href="/facts/Hypoxia_(medical)/JWV04G89">hypoxia</a>). The absence of <a href="/facts/Oxygen/acyn6o8r">oxygen</a> and <a href="/facts/Nutrient/34bn4skK">nutrients</a> from blood during the ischemic period creates a condition in which the restoration of <a href="/facts/Circulatory_system/WXwudzzc">circulation</a> results in <a href="/facts/Inflammation/Ura86MIy">inflammation</a> and <a href="/facts/Oxidation/Pyd5RVcj">oxidative</a> damage through the induction of <a href="/facts/Oxidative_stress/HX7dfUUb">oxidative stress</a> rather than (or along with) restoration of normal function.
Reperfusion injury is distinct from <a href="/facts/Cerebral_hyperperfusion_syndrome/E0u4uFNb">cerebral hyperperfusion syndrome</a> (sometimes called "Reperfusion syndrome"), a state of abnormal cerebral vasodilation.

Reperfusion injury open-in-new

Reperfusion injury