ATG16L1

Autophagy related 16 like 1 is a <a href="/facts/Protein/Jxmagu3E">protein</a> that in humans is encoded by the ATG16L1 <a href="/facts/Gene/e1swwPY6">gene</a>. This protein is characterized as a subunit of the <a href="/facts/Autophagy/kJC4QM9l">autophagy</a>-related <a href="/facts/ATG12/FvJn1yCh">ATG12-</a><a href="/facts/ATG5/2Ib28ASW">ATG5</a>/ATG16 complex and is essentially important for the LC3 (<a href="/facts/ATG8/7wwRMqsb">ATG8</a>) lipidation and <a href="/facts/Autophagosome/JoRbdUjU">autophagosome</a> formation. This complex localizes to the membrane and is released just before or after autophagosome completion.
Furthermore, ATG16L1 appears to have other autophagy-independent functions, e.g., intracellular membrane trafficking regulation and <a href="/facts/Inflammation/Ura86MIy">inflammation</a>. Autophagy in general plays a crucial role in pathways leading to <a href="/facts/Innate_immune_system/lz4BpSQI">innate</a> and <a href="/facts/Adaptive_immune_system/bc7zT1Jo">adaptive immunity</a> activation. That is why many autophagy-related proteins, including ATG16L1, their gene expression and its role in <a href="/facts/Autoimmune_disease/sojBeQ7t">autoimmune diseases</a> are studied in-depth nowadays.[when?]

ATG16L1 open-in-new

ATG16L1