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Isoprenaline
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<p>Isoprenaline, also known as isoproterenol and sold under the brand name Isuprel among others, is a <a href="/facts/Sympathomimetic/IEYU5ERW">sympathomimetic</a> <a href="/facts/Medication/h9mhwWP2">medication</a> which is used in the treatment of acute <a href="/facts/Bradycardia/70msP5HD">bradycardia</a> (slow heart rate), <a href="/facts/Heart_block/ehuFjb1H">heart block</a>, and rarely for <a href="/facts/Asthma/7GkJvxn3">asthma</a>, among other indications. It is used by <a href="/facts/Intravenous_administration/AwwuD3Nu">injection into a vein</a>, <a href="/facts/Intramuscular_injection/PPNwW2wB">muscle</a>, <a href="/facts/Subcutaneous_injection/L4srK61u">fat</a>, or the <a href="/facts/Intracardiac_injection/ykC1H2vY">heart</a>, by <a href="/facts/Inhalational_administration/eB5VlguF">inhalation</a>, and in the past <a href="/facts/Sublingual_administration/dSzR1gYG">under the tongue</a> or <a href="/facts/Rectal_administration/1Jvwy7Hb">into the rectum</a>. </p><p>Side effects of isoprenaline include <a href="/facts/Tachycardia/ycmyzP7q">rapid heart beat</a>, <a href="/facts/Palpitation/2wACMY49">heart palpitations</a>, and <a href="/facts/Arrhythmia/ooEpr46Q">arrhythmias</a>, among others. Isoprenaline is a <a href="/facts/Binding_selectivity/RryTsdGv">selective</a> <a href="/facts/Agonist/nz8U5NNp">agonist</a> of the <a href="/facts/%25CE%2592-adrenergic_receptor/uoAeJbcN">β-adrenergic receptors</a>, including both the <a href="/facts/%25CE%25921-adrenergic_receptor/ad3RAKPU">β1-</a> and <a href="/facts/%25CE%25922-adrenergic_receptor/erywpzGl">β2-adrenergic receptors</a>. By activating these <a href="/facts/Receptor_(biochemistry)/tjTAC76a">receptors</a>, it increases <a href="/facts/Heart_rate/YngB0bzg">heart rate</a> and the <a href="/facts/Myocardial_contractility/0BdQPIsv">force of heart contractions</a>. Chemically, isoprenaline is a <a href="/facts/Synthetic_compound/gqCNaN45">synthetic</a> <a href="/facts/Catecholamine/hHFrCMgM">catecholamine</a> and is the <i>N</i>-<a href="/facts/Isopropyl/fl8SMScE">isopropyl</a> <a href="/facts/Structural_analogue/3aysWSVG">analogue</a> of <a href="/facts/Norepinephrine/AjTIC9ox">norepinephrine</a> (noradrenaline) and <a href="/facts/Epinephrine/k7vvMI7E">epinephrine</a> (adrenaline). </p><p>Isoprenaline was one of the first <a href="/facts/Synthetic_compound/gqCNaN45">synthetic</a> <a href="/facts/Sympathomimetic/IEYU5ERW">sympathomimetic</a> <a href="/facts/Amine/JvfYJfP6">amines</a> and was the first <a href="/facts/Binding_selectivity/RryTsdGv">selective</a> β-adrenergic receptor agonist. The medication was discovered in 1940 and was introduced for medical use in 1947. </p>