Dynamic combinatorial chemistry

<p>Dynamic combinatorial chemistry (DCC); also known as constitutional dynamic chemistry (CDC) is a method to the generation of new molecules formed by <a href="/facts/Reversible_reaction/V3Afejgb">reversible reaction</a> of simple building blocks under <a href="/facts/Thermodynamic_control/HnnBoou1">thermodynamic control</a>. The library of these reversibly interconverting building blocks is called a dynamic combinatorial library (DCL). All constituents in a DCL are in <a href="/facts/Thermodynamic_equilibrium/1D7nGm0d">equilibrium</a>, and their distribution is determined by their <a href="/facts/Thermodynamic_stability/j0YIgc6F">thermodynamic stability</a> within the DCL. The interconversion of these building blocks may involve <a href="/facts/Covalent/EzMLf3Pz">covalent</a> or <a href="/facts/Non-covalent/J0pnJCe8">non-covalent</a> interactions. When a DCL is exposed to an external influence (such as <a href="/facts/Proteins/Jxmagu3E">proteins</a> or <a href="/facts/Nucleic_acids/2tTgcI0v">nucleic acids</a>), the equilibrium shifts and those components that interact with the external influence are <a href="/facts/Stabilizer_(chemistry)/lcQGnRUL">stabilised</a> and <a href="/facts/Amplification_(molecular_biology)/CcfJYsDF">amplified</a>, allowing more of the active compound to be formed.
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Dynamic combinatorial chemistry open-in-new

Dynamic combinatorial chemistry