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Reference.org
GTPase
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<p>GTPases are a large family of <a href="/facts/Hydrolase/XW89JvNF">hydrolase</a> <a href="/facts/Enzyme/DSI1Fh7y">enzymes</a> that bind to the <a href="/facts/Nucleotide/pQKEwlJI">nucleotide</a> <a href="/facts/Guanosine_triphosphate/NAwoHjTW">guanosine triphosphate (GTP)</a> and <a href="/facts/Hydrolysis/JTvwIHPs">hydrolyze</a> it to <a href="/facts/Guanosine_diphosphate/3BkkMql3">guanosine diphosphate (GDP)</a>. The GTP binding and hydrolysis takes place in the highly <a href="/facts/Conserved_sequence/YAxy2Xa2">conserved</a> <a href="/facts/P-loop/p49qD8FM">P-loop</a> "G domain", a <a href="/facts/Domain_(protein)/oUpFcSsl">protein domain</a> common to many GTPases. </p>