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Group I catalytic intron
open-in-new
<p>Group I introns are large self-splicing <a href="/facts/Ribozymes/yvcl3ygp">ribozymes</a>. They <a href="/facts/Biocatalysis/IM4JALIV">catalyze</a> their own excision from <a href="/facts/MRNA/oUL6qxQn">mRNA</a>, <a href="/facts/TRNA/pR9T5XSl">tRNA</a> and <a href="/facts/RRNA/zy5FxddY">rRNA</a> precursors in a wide range of organisms. The core <a href="/facts/Secondary_structure/VaN6MEYh">secondary structure</a> consists of nine paired regions (P1-P9). These fold to essentially two <a href="/facts/Protein_domains/oUpFcSsl">domains</a> – the P4-P6 domain (formed from the stacking of P5, P4, P6 and P6a helices) and the P3-P9 domain (formed from the P8, P3, P7 and P9 helices). The secondary structure mark-up for this family represents only this conserved core. Group I <a href="/facts/Introns/LS6YdBEK">introns</a> often have long <a href="/facts/Open_reading_frame/Saams83e">open reading frames</a> inserted in <a href="/facts/Stem-loop/GysAzrX5">loop regions</a>. </p>