Graphical models for protein structure

<p><a href="/facts/Graphical_model/XxfmKhmM">Graphical models</a> have become powerful frameworks for <a href="/facts/Protein_structure_prediction/sj6AbLjI">protein structure prediction</a>, <a href="/facts/Protein%25E2%2580%2593protein_interaction/etvm9Wmg">protein–protein interaction</a>, and <a href="/facts/Thermodynamic_free_energy/GtjtQqnq">free energy</a> calculations for protein structures. Using a graphical model to represent the protein structure allows the solution of many problems including secondary structure prediction, protein-protein interactions, protein-drug interaction, and free energy calculations.
</p><p>There are two main approaches to using graphical models in protein structure modeling. The first approach uses <a href="/facts/Discrete_mathematics/XdRUnzUL">discrete</a> variables for representing the coordinates or the <a href="/facts/Dihedral_angle/C9WEJsuS">dihedral angles</a> of the protein structure. The variables are originally all continuous values and, to transform them into discrete values, a discretization process is typically applied. The second approach uses continuous variables for the coordinates or dihedral angles.
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Graphical models for protein structure open-in-new

Graphical models for protein structure