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Anti-tetanus immunoglobulin
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<p>Anti-tetanus immunoglobulin, also known as tetanus immune globulin (TIG) and tetanus antitoxin, is a medication made up of <a href="/facts/Antibodies/MX8pdTdP">antibodies</a> against the <a href="/facts/Tetanus_toxin/Bd256bGq">tetanus toxin</a>. It is used to prevent <a href="/facts/Tetanus/1vukLxUU">tetanus</a> in those who have a wound that is at high risk, have not been fully <a href="/facts/Vaccinated/QcXzLug2">vaccinated</a> with <a href="/facts/Tetanus_toxoid/Ee1Bw1a9">tetanus toxoid</a>, or have <a href="/facts/HIV%2fAIDS/RqLIEMuJ">HIV/AIDS</a>. It is used to treat tetanus along with <a href="/facts/Antibiotics/sF1kIfxg">antibiotics</a> and <a href="/facts/Muscle_relaxants/9jtlSa90">muscle relaxants</a>. It is given by <a href="/facts/Intramuscular/PPNwW2wB">injection into a muscle</a>. Part of the dose is injected at the site of the wound. </p><p>Common side effects include pain at the site of injection and fever. <a href="/facts/Allergic_reactions/dYAVosh8">Allergic reactions</a> including <a href="/facts/Anaphylaxis/F9IDQxeL">anaphylaxis</a> may rarely occur. There is also a very low risk of the spread of infections such as <a href="/facts/Viral_hepatitis/DjT90Yhf">viral hepatitis</a> and <a href="/facts/HIV%2fAIDS/RqLIEMuJ">HIV/AIDS</a> with the human version. Use during <a href="/facts/Pregnancy/vEKYGpep">pregnancy</a> and <a href="/facts/Lactation/0w1HoW27">lactation</a> is acceptable. It is made from either human or horse <a href="/facts/Blood_plasma/oHuwwugG">blood plasma</a>. </p><p>The immunoglobulin is categorized as <a href="/facts/Immunoglobulin_G/cKzc83tk">immunoglobulin G</a> (IgG). Since the tetanus toxin permanently binds to human tissues, only unbounded molecules can be neutralized by the immunoglobulin. </p><p>Use of the horse version became common in the 1910s, while the human version came into frequent use in the 1960s. It is on the <a href="/facts/WHO_Model_List_of_Essential_Medicines/6kmu81Xm">World Health Organization's List of Essential Medicines</a>. The human version may be unavailable in the developing world. The horse version is not typically used in the <a href="/facts/Developed_world/sqwTSDHm">developed world</a> due to the risk of <a href="/facts/Serum_sickness/8TrV2bLx">serum sickness</a>. </p>