Plasmid-mediated resistance

<p>Plasmid-mediated resistance is the transfer of <a href="/facts/Antibiotic_resistance/jsbAywgx">antibiotic resistance</a> genes which are carried on <a href="/facts/Plasmid/yf59JVlA">plasmids</a>. Plasmids possess mechanisms that ensure their independent replication as well as those that regulate their replication number and guarantee stable inheritance during cell division. By the <a href="/facts/Bacterial_conjugation/WfeyKYC4">conjugation</a> process, they can stimulate lateral transfer between bacteria from various genera and kingdoms. Numerous plasmids contain addiction-inducing systems that are typically based on toxin-antitoxin factors and capable of killing daughter cells that don't inherit the plasmid during cell division. Plasmids often carry multiple <a href="/facts/Antibiotic_resistance/jsbAywgx">antibiotic resistance</a> genes, contributing to the spread of <a href="/facts/Multidrug_resistance/TPbHtAvz">multidrug-resistance</a> (MDR). Antibiotic resistance mediated by MDR plasmids severely limits the treatment options for the infections caused by <a href="/facts/Gram-negative_bacteria/S1PbVtp4">Gram-negative bacteria</a>, especially family <a href="/facts/Enterobacteriaceae/6vh55fHY">Enterobacteriaceae</a>. The global spread of MDR plasmids has been enhanced by <a href="/facts/Selective_pressure/8zrwXR50">selective pressure</a> from antimicrobial medications used in medical facilities and when raising animals for food.
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Plasmid-mediated resistance open-in-new

Plasmid-mediated resistance