PTPRC

Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an <a href="/facts/Enzyme/DSI1Fh7y">enzyme</a> that, in humans, is encoded by the PTPRC <a href="/facts/Gene/e1swwPY6">gene</a>. PTPRC is also known as CD45 <a href="/facts/Antigen/9JlAernG">antigen</a> (CD stands for <a href="/facts/Cluster_of_differentiation/cLEuDQId">cluster of differentiation</a>), which was originally called leukocyte common antigen (LCA).
PTPRC is a critical enzyme involved in regulating immune cell function. PTPRC is a transmembrane protein tyrosine phosphatase expressed on the surface of all nucleated <a href="/facts/Hematopoietic_cell/lf9GA0Dj">hematopoietic cells</a>, particularly <a href="/facts/Lymphocyte/pS2pv2Ma">lymphocytes</a>. It plays a key role in the activation and differentiation of <a href="/facts/T_cell/5z6PQ9UN">T cells</a>, <a href="/facts/B_cell/6Y1tgwwp">B cells</a>, and other immune cells by modulating signaling pathways. It functions by dephosphorylating specific tyrosine residues on target proteins, thereby controlling various signaling processes essential for <a href="/facts/Immune_response/dtLulqIy">immune response</a> and <a href="/facts/Homeostasis/rloTGAHa">homeostasis</a>.

PTPRC open-in-new

PTPRC