Post-stroke depression (PSD) is a form of depression that may occur after a stroke. PSD significantly impacts stroke recovery and the overall quality of life of those affected. It is particularly associated with strokes affecting the basal ganglia or the anterior regions of the brain, including the hippocampus and prefrontal cortex. Treatment can include medications such as SSRIs, SNRIs, tricyclic antidepressants, and/or cognitive behavioral therapy.