Raphe nuclei

<p>The raphe nuclei  are a moderate-size cluster of <a href="/facts/Nucleus_(neuroanatomy)/vGVMC1ox">nuclei</a> found in the <a href="/facts/Brain_stem/lD3WQbXM">brain stem</a>. They have <a href="/facts/5-HT1_receptor/c2tVGHCw">5-HT1 receptors</a> which are coupled with <a href="/facts/Heterotrimeric_G_protein/WUowu38d">Gi/Go-protein</a>-inhibiting <a href="/facts/Adenyl_cyclase/WnCSuV96">adenyl cyclase</a>. They function as <a href="/facts/Autoreceptor/m8FPWHcK">autoreceptors</a> in the brain and decrease the release of <a href="/facts/Serotonin/EzY58q4a">serotonin</a>. The <a href="/facts/Anxiolytic/uEWpGca9">anxiolytic</a> drug <a href="/facts/Buspirone/IeoGp3eD">Buspirone</a> acts as <a href="/facts/Partial_agonist/VLm2vmgU">partial agonist</a> against these receptors. <a href="/facts/Selective_serotonin_reuptake_inhibitor/L6jjcmEH">Selective serotonin reuptake inhibitor</a> (SSRI) <a href="/facts/Antidepressant/N62ND3Fa">antidepressants</a> are believed to act in these nuclei, as well as at their targets.
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Raphe nuclei open-in-new

Raphe nuclei