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Reference.org
Conformational ensembles
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<p>In <a href="/facts/Computational_chemistry/KyuCgRV3">computational chemistry</a>, conformational ensembles, also known as structural ensembles, are experimentally constrained computational models describing the structure of <a href="/facts/Intrinsically_unstructured_proteins/KrnRkv7K">intrinsically unstructured proteins</a>. Such proteins are flexible in nature, lacking a stable <a href="/facts/Protein_tertiary_structure/1QJVj1V1">tertiary structure</a>, and therefore cannot be described with a single structural representation. The techniques of ensemble calculation are relatively new on the field of <a href="/facts/Structural_biology/XRkPtHYv">structural biology</a>, and are still facing certain limitations that need to be addressed before it will become comparable to classical structural description methods such as <a href="/facts/X-ray_crystallography/WtI0F5DN">biological macromolecular crystallography</a>. </p>