Chelerythrine

Chelerythrine is a benzophenanthridine <a href="/facts/Alkaloid/m6hUXohz">alkaloid</a> present in the plant <a href="/facts/Greater_celandine/CVJP3GuN">Chelidonium majus</a> (greater celandine). It is a potent, selective, and cell-permeable <a href="/facts/Protein_kinase_C/6WSQgAWv">protein kinase C</a> <a href="/facts/Enzyme_inhibitor/MkFwGXHJ">inhibitor</a> <a href="/facts/In_vitro/evp3hAX6">in vitro</a>. And an efficacious <a href="/facts/Agonist/nz8U5NNp">antagonist</a> of <a href="/facts/G_protein%E2%80%93coupled_receptor/0arUMkQc">G-protein-coupled</a> <a href="/facts/Cannabinoid_receptor_type_1/7b2tfePV">CB1 receptors</a>. This molecule also exhibits anticancer qualities and it has served as a base for many potential novel drugs against cancer. Structurally, this molecule has two distinct conformations, one being a positively charged <a href="/facts/Iminium/eLFxYGI3">iminium form</a>, and the other being an uncharged form, a pseudo-base.
It is also found in the plants <a href="/facts/Zanthoxylum_clava-herculis/Ijx6THab">Zanthoxylum clava-herculis</a> and <a href="/facts/Zanthoxylum_rhoifolium/1bzzxXuQ">Zanthoxylum rhoifolium</a>, exhibiting antibacterial activity against <a href="/facts/Staphylococcus_aureus/9yDVBMsc">Staphylococcus aureus</a> and other human pathogens.

Chelerythrine open-in-new

Chelerythrine