Cancer Alley is the regional nickname given to an 85-mile (137 km) stretch of land along the Mississippi River between Baton Rouge and New Orleans, in the River Parishes of Louisiana, which contains over 200 petrochemical plants and refineries. As of 2012, this area accounted for 25% of the petrochemical production in the United States. By the 1970s the EPA documented serious water and air pollution. Environmentalists consider the region a sacrifice zone where rates of cancer caused by air pollution exceed the federal government's own limits of acceptable risk.
Community leaders such as Sharon Lavigne have led the charge in protesting the expansion of the petrochemical industry in Cancer Alley, as well as addressing the associated racial and economic disparities.
Cancer Alley in a larger sense extends further west along the Gulf Coast into Texas to the area of Freeport, Texas.