Alpha-enolase

<p>Enolase 1 (ENO1), more commonly known as alpha-enolase, is a <a href="/facts/Glycolysis/a5ApxLoG">glycolytic</a> <a href="/facts/Enzyme/DSI1Fh7y">enzyme</a> expressed in most tissues, one of the <a href="/facts/Isozyme/WE3tbEhf">isozymes</a> of <a href="/facts/Enolase/NkM6Yhfv">enolase</a>. Each isoenzyme is a <a href="/facts/Homodimer/c8LwFJPG">homodimer</a> composed of 2 alpha, 2 gamma, or 2 beta <a href="/facts/Protein_subunit/HhuET9UP">subunits</a>, and functions as a glycolytic enzyme. Alpha-enolase, in addition, functions as a structural <a href="/facts/Lens_(anatomy)/yWz7AdHV">lens</a> protein (<a href="/facts/Tau/gfvnmJoH">tau</a>-<a href="/facts/Crystallin/t9zo8ud4">crystallin</a>) in the <a href="/facts/Monomer/Gw3CltMb">monomeric</a> form. <a href="/facts/Alternative_splicing/nNRwPVNK">Alternative splicing</a> of this gene results in a shorter isoform that has been shown to bind to the <i><a href="/facts/C-myc/7FGlAtFk">c-myc</a></i> promoter and function as a <a href="/facts/Tumor_suppressor/Awte4S51">tumor suppressor</a>. Several <a href="/facts/Pseudogene/VfbL4L07">pseudogenes</a> have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an <a href="/facts/Autoantigen/5cASmcfI">autoantigen</a> in <a href="/facts/Hashimoto_encephalopathy/5U8QlP8c">Hashimoto encephalopathy</a>.
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Alpha-enolase open-in-new

Alpha-enolase