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Reference.org
BCCIP
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<p>BRCA2 and CDKN1A-interacting protein is a <a href="/facts/Protein/Jxmagu3E">protein</a> that is encoded by the <i>BCCIP</i> <a href="/facts/Gene/e1swwPY6">gene</a> in humans. </p><p>This gene product was isolated based on its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene. </p>