Hodgkin–Huxley model

<p>The Hodgkin–Huxley model, or conductance-based model, is a <a href="/facts/Mathematical_model/CGhyuxgz">mathematical model</a> that describes how <a href="/facts/Action_potential/Sz8yCRqx">action potentials</a> in <a href="/facts/Neuron/G7CyTVdH">neurons</a> are initiated and propagated. It is a set of <a href="/facts/Nonlinear_system/4aYItALC">nonlinear differential equations</a> that approximates the <a href="/facts/Electrical_engineering/YYXW1KLW">electrical engineering</a> characteristics of <a href="/facts/Excitable_cell/DpNG14c7">excitable cells</a> such as neurons and <a href="/facts/Muscle_cell/cP7Jea3q">muscle cells</a>. It is a continuous-time <a href="/facts/Dynamical_system/782gREl5">dynamical system</a>.
</p><p><a href="/facts/Alan_Hodgkin/YUY3C2Hd">Alan Hodgkin</a> and <a href="/facts/Andrew_Huxley/DzFkDD4W">Andrew Huxley</a> described the model in 1952 to explain the ionic mechanisms underlying the initiation and propagation of action potentials in the <a href="/facts/Squid_giant_axon/GneP9HPB">squid giant axon</a>.  They received the 1963 <a href="/facts/Nobel_Prize_in_Physiology_or_Medicine/rlnpJX84">Nobel Prize in Physiology or Medicine</a> for this work.
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Hodgkin–Huxley model open-in-new

Hodgkin–Huxley model