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PAPOLA
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<p>Poly(A) polymerase alpha is an <a href="/facts/Enzyme/DSI1Fh7y">enzyme</a> that in humans is encoded by the <i>PAPOLA</i> <a href="/facts/Gene/e1swwPY6">gene</a>. </p><p>PAPOLA binds to <a href="/facts/FIP1L1/VzGz3mXv">FIP1L1</a> (Factor interacting with PAPOLA and CPSF1), a subunit of the <a href="/facts/CPSF1/t75S82qo">cleavage and polyadenylation specificity factor subunit 1</a> (CPSF1) complex. This complex polyadenylates the <a href="/facts/Directionality_(molecular_biology)/TIAXEQmY">3' end</a> of <a href="/facts/Precursor_mRNA/4UXtKPHw">precursor mRNAs</a> (pre-mRNA) (see <a href="/facts/CPSF/15AqKWup">CPSF</a>). CPSF1 is an <a href="/facts/RNA/HxPeNfNj">RNA</a> processing protein that binds to <a href="/facts/Uracil/KUAcYYpQ">uracil</a>-rich sequences in pre-mRNA, binds with and stimulates PAPOLA's <a href="/facts/Polynucleotide_adenylyltransferase/9jValLwt">Polynucleotide adenylyltransferase</a> activity, and thereby adds <a href="/facts/Adenosine_monophosphate/D9Ryfqad">adenylyl</a> residues to pre-mRNA. This poly-adenylyl action increases pre mRNA's maturation and movement from the nucleus to cytoplasm while dramatically increasing the stability of the mRNA formed from pre-mRNA: FIP1L1 is a Pre-mRNA 3'-end-processing factor. <i>FIP1L1</i> <a href="/facts/Fusion_gene/AyR9DgQ8">gene fusions</a> between it and either the <a href="/facts/PDGFRA/S83WxqcQ">platelet-derived growth factor receptor, alpha (<i>PGDFRA</i>)</a> or <a href="/facts/Retinoic_acid_receptor_alpha/KPJoX9MP">Retinoic acid receptor alpha</a> (RARA) genes are causes of certain human <a href="/facts/Hypereosinophilia/RkFrKK10">diseases associated with pathologically increased levels of blood eosinophils</a> and/or <a href="/facts/Leukemia/WpEfW0Qh">Leukemias</a>. </p>