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Neointimal hyperplasia
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<p>Neointimal hyperplasia refers to proliferation and migration of vascular <a href="/facts/Smooth_muscle_cell/mpcpTsHp">smooth muscle cells</a> primarily in the <a href="/facts/Tunica_intima/x8gCjsuG">tunica intima</a>, resulting in the thickening of <a href="/facts/Arterial_wall/Y1Yj0jat">arterial walls</a> and decreased arterial <a href="/facts/Lumen_(anatomy)/3thJT4Hf">lumen</a> space. Neointimal hyperplasia is the major cause of <a href="/facts/Restenosis/cKNYGX9z">restenosis</a> after percutaneous coronary interventions such as <a href="/facts/Stent/h8Ss3zlE">stenting</a> or <a href="/facts/Angioplasty/j2ausFmb">angioplasty</a>. The term neointima is used because the cells in the hyperplastic regions of the vascular wall have <a href="/facts/Histological/yrI90zlU">histological</a> characteristics of both intima and normal artery cells. </p>