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Thiourea organocatalysis
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<p>Within the area of <a href="/facts/Organocatalysis/oR5c1RDJ">organocatalysis</a>, (thio)urea organocatalysis describes the use of <a href="/facts/Urea/6j84AoCG">ureas</a> and <a href="/facts/Thiourea/69a3dfSc">thioureas</a> to accelerate and stereochemically alter organic transformations. The effects arise through <a href="/facts/Hydrogen-bonding/85V86IIg">hydrogen-bonding</a> interactions between the substrate and the (thio)urea. Unlike classical catalysts, these organocatalysts interact by non-covalent interactions, especially <a href="/facts/Hydrogen-bond_catalysis/mHyVpU4k">hydrogen bonding</a> ("partial <a href="/facts/Protonation/q5Gf9z0M">protonation</a>"). The scope of these small-molecule H-bond donors termed (thio)urea <a href="/facts/Organocatalysis/oR5c1RDJ">organocatalysis</a> covers both non-stereoselective and stereoselective reactions. </p>