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Reference.org
HAND1
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<p>Heart- and neural crest derivatives-expressed protein 1 is a <a href="/facts/Protein/Jxmagu3E">protein</a> that in humans is encoded by the <i>HAND1</i> <a href="/facts/Gene/e1swwPY6">gene</a>. </p><p>A member of the HAND subclass of <a href="/facts/Basic_helix-loop-helix/yqfuWejn">basic Helix-loop-helix (bHLH)</a> transcription factors, the Heart and neural crest-derived transcript-1 (<i>HAND1)</i> gene is vital for the development and differentiation of three distinct embryological lineages including the cardiac muscle cells of the heart, trophoblast of the placenta, and yolk sac vasculogenesis. Most highly related to <a href="/facts/Twist_transcription_factor/lTIjHaUq">twist-like bHLH genes</a> in amino acid identity and embryonic expression, HAND1 can form homo- and heterodimer combinations with multiple bHLH partners, mediating transcriptional activity in the nucleus. </p>