Clomethiazole

<p>Clomethiazole (also called chlormethiazole) is a <a href="/facts/Sedative/JWzvq66P">sedative</a> and <a href="/facts/Hypnotic/0SBVYkMe">hypnotic</a> originally developed by <a href="/facts/Roche/hHVcLCXb">Hoffmann-La Roche</a> in the 1930s. The drug is typically used in treating and preventing symptoms of acute alcohol withdrawal, <a href="/facts/Anxiety/Geekl883">anxiety</a> and as a sedative-hypnotic.
</p><p>It is structurally related to <a href="/facts/Thiamine/37RC4MCS">thiamine</a> (vitamin B1), but acts like a sedative, hypnotic, <a href="/facts/Anxiolytic/uEWpGca9">anxiolytic</a>, <a href="/facts/Muscle_relaxant/9jtlSa90">muscle relaxant</a> and <a href="/facts/Anticonvulsant/uR8cxJbj">anticonvulsant</a>, having the same mechanism of action as traditional barbiturates. It is also used for the management of <a href="/facts/Psychomotor_agitation/n1vWk6RD">agitation</a>, restlessness, and <a href="/facts/Parkinson%2527s_disease/xpekKj6x">Parkinson's disease</a>. In the <a href="/facts/United_Kingdom/kuPAILt2">UK</a>, it is sold under the brand Heminevrin (<a href="/facts/AstraZeneca/KTPcnWfE">AstraZeneca Pharmaceuticals</a>). Other brand names include Nevrin in Romania, Distraneurin in <a href="/facts/Germany/paluuWBX">Germany</a> and Distraneurine in Spain. The drug is marketed either as a <a href="/facts/Free_base_(chemistry)/bLMkVbTk">free base</a> in an oily solution containing 192 mg in capsule form, or as clomethiazole <a href="/facts/Ethanedisulfonic_acid/8JNtp2mT">edisylate</a> syrup. Due to its high toxicity compared to <a href="/facts/Benzodiazepines/IgbJr4jy">benzodiazepines</a> it is not recommended as a first-line treatment for any indication and is particularly dangerous to patients with an elevated risk for drug abuse such as those with a personal or familial history of addiction.
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Clomethiazole open-in-new

Clomethiazole