Natural resistance-associated macrophage protein 2

Natural resistance-associated macrophage protein 2 (NRAMP 2), also known as divalent metal transporter 1 (DMT1) and divalent cation transporter 1 (DCT1), is a <a href="/facts/Protein/Jxmagu3E">protein</a> that in humans is encoded by the SLC11A2 (solute carrier family 11, member 2) <a href="/facts/Gene/e1swwPY6">gene</a>. DMT1 represents a large family of <a href="/facts/Homology_(biology)/muctKlyT">orthologous</a> metal ion transporter proteins that are highly conserved from bacteria to humans.
As its name suggests, DMT1 binds a variety of divalent metals including <a href="/facts/Cadmium/wXkV2eIX">cadmium</a> (Cd2+), <a href="/facts/Copper/I8PEE8oX">copper</a> (Cu2+), and <a href="/facts/Zinc/80b1qgk3">zinc</a> (Zn2+,); however, it is best known for its role in transporting ferrous <a href="/facts/Iron/QK1JYy8E">iron</a> (Fe2+). DMT1 expression is regulated by body iron stores to maintain iron homeostasis. DMT1 is also important in the absorption and transport of <a href="/facts/Manganese/j9ELd1TL">manganese</a> (Mn2+). In the digestive tract, it is located on the apical membrane of <a href="/facts/Enterocytes/NfAsbB9s">enterocytes</a>, where it carries out H+-coupled transport of divalent metal cations from the intestinal lumen into the cell.

Natural resistance-associated macrophage protein 2 open-in-new

Natural resistance-associated macrophage protein 2