The St. Louis County Depot is a historic railroad station in Duluth, Minnesota, United States. It was built as a union station in 1892, serving seven railroads at its peak. Rail service ceased in 1969 and the building was threatened with demolition until it reopened in 1973 as St. Louis County Heritage & Arts Center (The Depot). Train service also resumed from 1974 to 1985, by Amtrak.
Owned today by St. Louis County, the building houses two museums (Lake Superior Railroad Museum, and St. Louis County Historical Society Museum), two performing arts organizations (DSSO and Minnesota Ballet), and serves as the departure point for the North Shore Scenic Railroad.