PPAP2B

<p>Lipid phosphate phosphohydrolase 3 (LPP3), also known as <a href="/facts/Phospholipid/u6GhNCF5">phospholipid</a> <a href="/facts/Phosphatase/LBJs1fXx">phosphatase</a> 3 (PLPP3) and <a href="/facts/Phosphatidic_acid_phosphatase/7RLQ6SJr">phosphatidic acid phosphatase</a> type 2B (PAP-2b or PPAP2B), is an <a href="/facts/Enzyme/DSI1Fh7y">enzyme</a> that in humans is encoded by the <i>PPAP2B</i> <a href="/facts/Gene/e1swwPY6">gene</a> on <a href="/facts/Chromosome_1_(human)/2ujmYz2w">chromosome 1</a>. It is ubiquitously expressed in many tissues and cell types. LPP3 is a <a href="/facts/Cell-surface/vAXSD0DT">cell-surface</a> <a href="/facts/Glycoprotein/bKPzzW7m">glycoprotein</a> that <a href="/facts/Hydrolysis/JTvwIHPs">hydrolyzes</a> <a href="/facts/Extracellular/UEPUhSN8">extracellular</a> <a href="/facts/Lysophosphatidic_acid/qG7BkYzG">lysophosphatidic acid</a> (LPA) and short-chain phosphatidic acid. Its function allows it to regulate <a href="/facts/Blood_vessel/FG3GjPNW">vascular</a> and <a href="/facts/Embryonic_development/1lFY4EoW">embryonic development</a> by inhibiting LPA signaling, which is associated with a wide range of human diseases, including <a href="/facts/Cardiovascular_disease/HD420nMv">cardiovascular disease</a> and <a href="/facts/Cancer/PVW6n1D0">cancer</a>, as well as developmental defects. The PPAP2B gene also contains one of 27 <a href="/facts/Locus_(genetics)/JcIT8wLm">loci</a> associated with increased risk of <a href="/facts/Coronary_artery_disease/szCt0nVx">coronary artery disease</a>.
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PPAP2B open-in-new

PPAP2B