Protein c-Fos

<p>Protein c-Fos is a <a href="/facts/Proto-oncogene/WLFu6Ma5">proto-oncogene</a> that is the human homolog of the retroviral <a href="/facts/Oncogene/WLFu6Ma5">oncogene</a> v-fos. It is encoded in humans by the <i>FOS</i> gene. It was first discovered in rat <a href="/facts/Fibroblasts/n08KsFll">fibroblasts</a> as the transforming gene of the FBJ MSV (Finkel–Biskis–Jinkins murine osteogenic sarcoma virus) (Curran and Tech, 1982). It is a part of a bigger Fos family of <a href="/facts/Transcription_factors/wro0DPHe">transcription factors</a> which includes c-Fos, <a href="/facts/FosB/KHElvauK">FosB</a>, <a href="/facts/Fra-1/gXKDGqaj">Fra-1</a> and <a href="/facts/Fra-2/t3pcsTmd">Fra-2</a>. It has been mapped to chromosome region 14q21→q31. c-Fos encodes a 62 kDa protein, which forms heterodimer with <a href="/facts/C-jun/Cbvb15yT">c-jun</a> (part of Jun family of transcription factors), resulting in the formation of <a href="/facts/AP-1_transcription_factor/jryICv0m">AP-1</a> (Activator Protein-1) complex which binds DNA at AP-1 specific sites at the promoter and enhancer regions of target genes and converts extracellular signals into changes of gene expression. It plays an important role in many cellular functions and has been found to be overexpressed in a variety of cancers.
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Protein c-Fos open-in-new

Protein c-Fos