Mechanism of action

In <a href="/facts/Pharmacology/4Rx8s7Ie">pharmacology</a>, the term mechanism of action (MOA) refers to the specific biochemical <a href="/facts/Drug_interaction/T5VcSVGd">interaction</a> through which a <a href="/facts/Medication/h9mhwWP2">drug</a> substance produces its <a href="/facts/Pharmacological_effect/jJ14jyvc">pharmacological effect</a>. A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an <a href="/facts/Enzyme/DSI1Fh7y">enzyme</a> or <a href="/facts/Receptor_(biochemistry)/tjTAC76a">receptor</a>. Receptor sites have specific affinities for drugs based on the chemical structure of the drug, as well as the specific action that occurs there.
Drugs that do not bind to receptors produce their corresponding therapeutic effect by simply interacting with chemical or physical properties in the body. Common examples of drugs that work in this way are <a href="/facts/Antacid/CP9PeyQ8">antacids</a> and <a href="/facts/Laxative/Sd8bddoF">laxatives</a>.
In contrast, a <a href="/facts/Mode_of_action/NT1TCXTS">mode of action (MoA)</a> describes functional or anatomical changes, at the cellular level, resulting from the exposure of a living organism to a substance.

Mechanism of action open-in-new

Mechanism of action