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Fixed-dose procedure
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<p>The fixed-dose procedure (FDP), proposed in 1992 by the <a href="/facts/British_Toxicology_Society/cmvKP3QH">British Toxicology Society</a>, is a method to assess a substance's acute oral <a href="/facts/Toxicity/qa96rs60">toxicity</a>. </p><p>In comparison to the older <a href="/facts/Median_lethal_dose/PSTer8Wv">LD50</a> test developed in 1927, this procedure produces similar results while using fewer animals and causing less pain and suffering. As a result, in 1992 this test was proposed as an alternative to the LD50 test by the <a href="/facts/Organisation_for_Economic_Co-operation_and_Development/CI9W2zGv">Organisation for Economic Co-operation and Development</a> under OECD Test Guideline 420. However, the U.S. Food and Drug Administration has begun to approve non-animal alternatives in response to research cruelty concerns and the lack of validity/sensitivity of animal tests as they relate to humans. </p>