Fluoxetine

Fluoxetine, sold under the brand name Prozac, among others, is an <a href="/facts/Antidepressant/N62ND3Fa">antidepressant medication</a> of the <a href="/facts/Selective_serotonin_reuptake_inhibitor/L6jjcmEH">selective serotonin reuptake inhibitor</a> (SSRI) class used for the treatment of <a href="/facts/Major_depressive_disorder/l2lQeWqr">major depressive disorder</a>, <a href="/facts/Anxiety_disorder/wh9zFH1V">anxiety</a>, <a href="/facts/Obsessive%25E2%2580%2593compulsive_disorder/bIhDh4dz">obsessive–compulsive disorder</a> (OCD), <a href="/facts/Panic_disorder/jRfhx14r">panic disorder</a>, <a href="/facts/Premenstrual_dysphoric_disorder/zmg0b1rX">premenstrual dysphoric disorder</a>, and <a href="/facts/Bulimia_nervosa/vha4lPpd">bulimia nervosa</a>. It is also approved for treatment of major depressive disorder in adolescents and children 8 years of age and over. It has also been used to treat <a href="/facts/Premature_ejaculation/SFCHo2KE">premature ejaculation</a>. Fluoxetine is <a href="/facts/Oral_administration/vNQcvLVx">taken by mouth</a>.
Common side effects include <a href="/facts/Anorexia_(symptom)/G7RsaXp9">loss of appetite</a>, <a href="/facts/Nausea/dyhkcbeD">nausea</a>, <a href="/facts/Diarrhea/6TBHaRdA">diarrhea</a>, <a href="/facts/Headache/mdmmC9DP">headache</a>, <a href="/facts/Insomnia/C1TnQTb2">trouble sleeping</a>, <a href="/facts/Dry_mouth/aKMwe59z">dry mouth</a>, and <a href="/facts/Sexual_dysfunction/cnrj9YDF">sexual dysfunction</a>. Serious side effects include <a href="/facts/Serotonin_syndrome/PqLvx901">serotonin syndrome</a>, <a href="/facts/Mania/qYV8BBbt">mania</a>, <a href="/facts/Seizures/zuIrQyze">seizures</a>, an increased risk of <a href="/facts/Suicidal_behavior/j92cWcay">suicidal behavior</a> in people under 25 years old, and an increased risk of bleeding. <a href="/facts/Antidepressant_discontinuation_syndrome/XlkjJFYA">Antidepressant discontinuation syndrome</a> is less likely to occur with fluoxetine than with other antidepressants. Fluoxetine taken during pregnancy is associated with a significant increase in <a href="/facts/Congenital_heart_defect/QsuPPC2Y">congenital heart defects</a> in newborns. It has been suggested that fluoxetine therapy may be continued during <a href="/facts/Breastfeeding/cdWXyYDX">breastfeeding</a> if it was used during pregnancy or if other antidepressants were ineffective.
Fluoxetine was invented by <a href="/facts/Eli_Lilly_and_Company/e5Pw7RmR">Eli Lilly and Company</a> in 1972 and entered medical use in 1986. It is on the <a href="/facts/WHO_Model_List_of_Essential_Medicines/6kmu81Xm">World Health Organization's List of Essential Medicines</a>. It is available as a <a href="/facts/Generic_medication/IF6AXDVX">generic medication</a>. In 2022, it was the 22nd most commonly prescribed medication in the United States, with more than 24 million prescriptions.
Eli Lilly also markets fluoxetine in a fixed-dose combination with <a href="/facts/Olanzapine/8BhqJuPM">olanzapine</a> as <a href="/facts/Olanzapine%2ffluoxetine/4ug300tF">olanzapine/fluoxetine</a> (Symbyax), which was approved by the US <a href="/facts/Food_and_Drug_Administration/rCEnh9WB">Food and Drug Administration</a> (FDA) for the treatment of depressive episodes of <a href="/facts/Bipolar_I_disorder/YWtzmKGI">bipolar I disorder</a> in 2003 and for <a href="/facts/Treatment-resistant_depression/0JM2IcFa">treatment-resistant depression</a> in 2009.

Fluoxetine open-in-new

Fluoxetine