Heparin-binding EGF-like growth factor

Heparin-binding EGF-like growth factor (HB-EGF) is a member of the <a href="/facts/Epidermal_growth_factor/CpyH5tYs">EGF family</a> of proteins that in humans is encoded by the HBEGF <a href="/facts/Gene/e1swwPY6">gene</a>.
HB-EGF-like growth factor is synthesized as a membrane-anchored <a href="/facts/Mitogenic/AyjRuS2a">mitogenic</a> and <a href="/facts/Chemotactic/hYPRdPTk">chemotactic</a> <a href="/facts/Glycoprotein/bKPzzW7m">glycoprotein</a>. An epidermal growth factor produced by monocytes and macrophages, due to an affinity for <a href="/facts/Heparin/4lxSm2pB">heparin</a> is termed HB-EGF. It has been shown to play a role in <a href="/facts/Wound_healing/3NlzV5Qn">wound healing</a>, <a href="/facts/Organ_hypertrophy/4JolPfnS">cardiac hypertrophy</a>, and <a href="/facts/Heart_development/wL9UQjsb">heart development</a> and function. First identified in the conditioned media of human macrophage-like cells, HB-EGF is an 87-amino acid glycoprotein that displays highly regulated gene expression. Ectodomain shedding results in the soluble mature form of HB-EGF, which influences the mitogenicity and chemotactic factors for smooth muscle cells and fibroblasts. The transmembrane form of HB-EGF is the unique receptor for <a href="/facts/Diphtheria_toxin/ap7Ry3Qa">diphtheria toxin</a> and functions in juxtacrine signaling in cells. Both forms of HB-EGF participate in normal physiological processes and in pathological processes including tumor progression and metastasis, organ <a href="/facts/Hyperplasia/gDv6kB4j">hyperplasia</a>, and atherosclerotic disease. HB-EGF can bind two locations on cell surfaces: heparan sulfate proteoglycans and EGF-receptors effecting cell-to-cell interactions.

Heparin-binding EGF-like growth factor open-in-new

Heparin-binding EGF-like growth factor