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Mukaiyama aldol addition
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<table><tbody><tr><th>educts</th></tr><tr><td> <a href="/facts/Aldehyde/xSIRkW03">aldehyde</a> (R1 = Alkyl, Aryl) or <a href="/facts/Formate/Py3GhI7L">formate</a> (R1 = OR)</td></tr><tr><td> <a href="/facts/Silyl_enol_ether/yKsCUUlV">silyl enol ether</a> (R1 = Alkyl, Aryl, H; R2 = Alkyl, Aryl, H, OR, SR)</td></tr></tbody></table> <p>In <a href="/facts/Organic_chemistry/djxhxaNg">organic chemistry</a>, the Mukaiyama aldol addition is an <a href="/facts/Organic_reaction/SESmeGWm">organic reaction</a> and a type of <a href="/facts/Aldol_reaction/L194Bx0g">aldol reaction</a> between a <a href="/facts/Silyl_enol_ether/yKsCUUlV">silyl enol ether</a> (R2C=CR−O−Si(CH3)3) and an <a href="/facts/Aldehyde/xSIRkW03">aldehyde</a> (R−CH=O) or <a href="/facts/Formate/Py3GhI7L">formate</a> (R−O−CH=O). The reaction was discovered by <a href="/facts/Teruaki_Mukaiyama/GPqv1MMI">Teruaki Mukaiyama</a> in 1973. His choice of reactants allows for a crossed aldol reaction between an aldehyde and a <a href="/facts/Ketone/BqQXpLo4">ketone</a> (>C=O), or a different aldehyde without <a href="/facts/Self-condensation/rnsHW3k4">self-condensation</a> of the aldehyde. For this reason the reaction is used extensively in <a href="/facts/Organic_synthesis/WLFePEzH">organic synthesis</a>. </p>