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GRAP
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<p>GRB2-related adapter protein is a <a href="/facts/Protein/Jxmagu3E">protein</a> that in humans is encoded by the <i>GRAP</i> <a href="/facts/Gene/e1swwPY6">gene</a>. </p><p>This gene encodes a member of the <a href="/facts/Grb2/uaFzqAbM">GRB2</a>/Sem5 (<i><a href="/facts/Caenorhabditis_elegans/XJVJzPn2">C. elegans</a></i> homolog)/Drk (<i><a href="/facts/Drosophila/P4K7RkJl">Drosophila</a></i> homolog) family. This member functions as a <a href="/facts/Cytoplasmic/Wa0sE6xf">cytoplasmic</a> signaling protein which contains an <a href="/facts/SH2_domain/1kEmHvzY">SH2 domain</a> flanked by two <a href="/facts/SH3_domain/aFNwnKe8">SH3 domains</a>. The SH2 domain interacts with <a href="/facts/Ligand/6etB3qeW">ligand</a>-activated receptors for <a href="/facts/Stem_cell/qgB9dFrI">stem cell</a> factor and <a href="/facts/Erythropoietin/jgYFo1R6">erythropoietin</a>, and facilitates the formation of a stable complex with the <a href="/facts/BCR_gene/gtljPQSu">BCR</a>-<a href="/facts/Abl_gene/h9pJd4jf">ABL</a> <a href="/facts/Oncoprotein/WLFu6Ma5">oncoprotein</a>. This protein also associates with the <a href="/facts/Ras_(protein)/JB883YoM">Ras</a> <a href="/facts/Guanine/hoTSpz0x">guanine</a> <a href="/facts/Nucleotide/pQKEwlJI">nucleotide</a> exchange factor <a href="/facts/SOS1/IlYU6w5U">SOS1</a> (son of sevenless homolog 1) through its N-terminal SH3 domain. </p>