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cAMP responsive element modulator
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<p>cAMP responsive element modulator is a <a href="/facts/Protein/Jxmagu3E">protein</a> that in humans is encoded by the CREM <a href="/facts/Gene/e1swwPY6">gene</a>, and it belongs to the <a href="/facts/Cyclic_adenosine_monophosphate/flK2vwUe">cAMP</a>-responsive element binding protein family. It has multiple isoforms, which act either as repressors or activators. CREB family is important for in regulating transcription in response to various stresses, metabolic and developmental signals. CREM transcription factors also play an important role in many physiological systems, such as cardiac function, circadian rhythms, locomotion and spermatogenesis. </p>