Noncoding RNA Activated by DNA Damage

<p>Noncoding RNA Activated by <a href="/facts/DNA/nB89Iauz">DNA</a> Damage (NORAD) is a long non-coding RNA (<a href="/facts/Long_non-coding_RNA/FHyAb6hP">lncRNA</a>) that responds to DNA damage and plays a significant role in preserving stability (keeping it accurate and unchanged) of genetic information (<a href="/facts/Genome/31Sm08JT">genome</a>) within cells. Upon DNA damage, the amount of NORAD increases within cells and work to prevent proteins responsible for stabilizing genomes (PUMILIO proteins) such as <a href="/facts/PUM1/r0MLPhw0">PUM1</a> and <a href="/facts/PUM2/n3f5H19Q">PUM2</a> from reaching their <a href="/facts/Messenger_RNA/oUL6qxQn">mRNA</a> targets and destabilizing them. By sequestering the PUMILIO proteins, NORAD allows the involved mRNA (pieces of genetic information derived from DNA that act as protein-coding messengers), to exert their function and maintain many cellular processes. These functions include the repair of the DNA itself, the control of <a href="/facts/Cell_division/n5MrunWj">cell division</a>, and the proper segregation of <a href="/facts/Chromosome/FRGf11FC">chromosomes</a>, which are tightly bundled forms of DNA. Lack of enough NORAD can cause <a href="/facts/Aneuploidy/CmaGcLIY">aneuploidy</a> as a possible result, which is an improper segregation of chromosomes that can be extremely harmful in proper cell division and in the creation of healthy gametes like <a href="/facts/Sperm/RCxpXygQ">sperm</a> and <a href="/facts/Egg_cell/gJyW3W3W">egg cells</a>.
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Noncoding RNA Activated by DNA Damage