Nicotinamide adenine dinucleotide phosphate

<p>Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a <a href="/facts/Cofactor_(biochemistry)/AGo0PCUU">cofactor</a> used in <a href="/facts/Anabolic_reaction/WxDrm8k5">anabolic reactions</a>, such as the <a href="/facts/Calvin_cycle/M1bIgQb9">Calvin cycle</a> and <a href="/facts/Lipid/TdQR87HX">lipid</a> and <a href="/facts/Nucleic_acid/2tTgcI0v">nucleic acid</a> syntheses, which require NADPH as a <a href="/facts/Reducing_agent/CtfSGVXC">reducing agent</a> ('hydrogen source'). NADPH is the <a href="/facts/Redox/Pyd5RVcj">reduced</a> form, whereas NADP+ is the <a href="/facts/Redox/Pyd5RVcj">oxidized</a> form. NADP+ is used by all forms of cellular life. NADP+ is essential for life because it is needed for cellular respiration.
</p><p>NADP+ differs from <a href="/facts/NAD%252B/BHdLW925">NAD+</a> by the presence of an additional <a href="/facts/Phosphate_group/FDGVCxUG">phosphate group</a> on the 2' position of the <a href="/facts/Ribose/VFKYCzPV">ribose</a> ring that carries the <a href="/facts/Adenine/PSeDFBnl">adenine</a> <a href="/facts/Moiety_(chemistry)/WxKqcJe1">moiety</a>. This extra phosphate is added by <a href="/facts/NAD%252B_kinase/LHPEGvup">NAD+ kinase</a> and removed by NADP+ phosphatase.
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Nicotinamide adenine dinucleotide phosphate open-in-new

Nicotinamide adenine dinucleotide phosphate