The 2016 Istanbul Open (also known as the TEB BNP Paribas Istanbul Open for sponsorship purposes) was a men's tennis tournament played on outdoor clay courts. It was the second edition of the Istanbul Open, and an ATP World Tour 250 event. It took place at the Koza World of Sports Arena in Istanbul, Turkey, from 25 April until 1 May 2016. Unseeded Diego Schwartzman won the singles title.