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Reference.org
5-HT1A receptor
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<p>The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of <a href="/facts/Serotonin_receptor/D6656QzQ">serotonin receptors</a>, or 5-HT receptors, that binds <a href="/facts/Serotonin/EzY58q4a">serotonin</a>, also known as 5-HT, a <a href="/facts/Neurotransmitter/LlpYFSU3">neurotransmitter</a>. 5-HT1A is expressed in the <a href="/facts/Brain/Xo5ABfXl">brain</a>, <a href="/facts/Spleen/6NKn9d8s">spleen</a>, and neonatal <a href="/facts/Kidney/HBspPrv9">kidney</a>. It is a <a href="/facts/G_protein-coupled_receptor/0arUMkQc">G protein-coupled receptor</a> (GPCR), coupled to the <a href="/facts/Gi_protein/ua0jmvM5">Gi protein</a>, and its activation in the brain mediates hyperpolarization and reduction of firing rate of the postsynaptic neuron. In humans, the serotonin 1A receptor is encoded by the HTR1A <a href="/facts/Gene/e1swwPY6">gene</a>. </p>