East Palestine is a village in Columbiana County, Ohio, United States. The population was 4,761 at the 2020 census. Located on the state's border with Pennsylvania, East Palestine is about 20 miles (32 km) south of Youngstown and 40 miles (64 km) northwest of Pittsburgh.
The city was home to industries in ceramics and tire manufacturing from the 1870s until the mid-1960s. East Palestine is located along the Norfolk Southern Railway and has a freight train station. In 2023, the village was near the site of a major train derailment that spilled vinyl chloride and triggered significant evacuations in the jurisdiction.