rs1800955

<p>In <a href="/facts/Genetics/bu8wne0A">genetics</a>, rs1800955 (also written as C-521T and -521C/T) is a <a href="/facts/Single_nucleotide_polymorphism/Qy5Y2wom">single nucleotide polymorphism</a> (SNP).
It is located in the <a href="/facts/Promotor_(biology)/YDYBzLfg">promoter</a> region of the <i><a href="/facts/DRD4/26otIqul">DRD4</a></i> gene.
This gene codes for the <a href="/facts/Dopamine_receptor/fgsjJwkL">dopamine receptor</a> D4.
</p><p>Due to the <a href="/facts/Dopamine_hypothesis_of_schizophrenia/txyuQsjl">dopamine hypothesis of schizophrenia</a> the SNP has been investigated for link to <a href="/facts/Schizophrenia/FMP4lQ57">schizophrenia</a>, and it may be slightly associated with this disorder.
</p><p>The SNP has been investigated with respect to <a href="/facts/Novelty_seeking/LaeB4zVX">novelty seeking</a>, — a <a href="/facts/Personality_trait/Iun5UFdX">personality trait</a> that may be measured with the <a href="/facts/Temperament_and_Character_Inventory/QlLKqcSC">Temperament and Character Inventory</a>.
A 2008 <a href="/facts/Meta-analysis/IcfChd8z">meta-analysis</a> indicates a possible association between novelty seeking and C-521T though rather small.
</p>

<h3>Other</h3>
<ul><li><a href="http://www.nature.com/mp/journal/v11/n10/fig_tab/4001869t4.html">Table 4</a> from "The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes"</li></ul>

rs1800955 open-in-new

rs1800955