Ziprasidone

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Ziprasidone, sold under the brand name Geodon among others, is an <a href="/facts/Atypical_antipsychotic/PQYUYXMu">atypical antipsychotic</a> used to treat <a href="/facts/Schizophrenia/FMP4lQ57">schizophrenia</a> and <a href="/facts/Bipolar_disorder/aMDwXbV0">bipolar disorder</a>. It may be used <a href="/facts/Oral_administration/vNQcvLVx">by mouth</a> and by <a href="/facts/Intramuscular/PPNwW2wB">injection into a muscle</a> (IM). The intramuscular form may be used for acute <a href="/facts/Psychomotor_agitation/n1vWk6RD">agitation</a> in people with schizophrenia.
Common side effects include <a href="/facts/Tremor/rD6ogM7X">tremors</a>, <a href="/facts/Fasciculation/zUfJuPMQ">tics</a>, <a href="/facts/Dizziness/eI8UvmS5">dizziness</a>, <a href="/facts/Dry_mouth/aKMwe59z">dry mouth</a>, <a href="/facts/Akathisia/hFUb0Uqr">restlessness</a>, <a href="/facts/Nausea/dyhkcbeD">nausea</a>, and mild <a href="/facts/Somnolence/mIlFhyf0">sedation</a>. Although it can also cause <a href="/facts/Weight_gain/jVbY8Eao">weight gain</a>, the risk is much lower than for other atypical antipsychotics. How it works is not entirely clear but is believed to involve effects on <a href="/facts/Serotonin/EzY58q4a">serotonin</a> and <a href="/facts/Dopamine/5gNy8Xkd">dopamine</a> in the <a href="/facts/Brain/Xo5ABfXl">brain</a>.
Ziprasidone was approved for medical use in the United States in 2001. The pills are made up of the hydrochloride salt, ziprasidone hydrochloride. The intramuscular form is the <a href="/facts/Mesylate/h0GRcGo6">mesylate</a>, ziprasidone mesylate trihydrate, and is provided as a <a href="/facts/Lyophilized/aURqwbrQ">lyophilized</a> powder. In 2020, it was the 282nd most commonly prescribed medication in the United States, with more than 1 million prescriptions.

Ziprasidone open-in-new

Ziprasidone