Helium (2He) (standard atomic weight: 4.002602(2)) has nine known isotopes, but only helium-3 (3He) and helium-4 (4He) are stable. All radioisotopes are short-lived; the longest-lived is 6He with half-life 806.92(24) milliseconds. The least stable is 10He, with half-life 260(40) yoctoseconds (2.6(4)×10−22 s), though 2He may have an even shorter half-life.
In Earth's atmosphere, the ratio of 3He to 4He is 1.343(13)×10−6. However, the isotopic abundance of helium varies greatly depending on its origin. In the Local Interstellar Cloud, the proportion of 3He to 4He is 1.62(29)×10−4, which is ~121 times higher than in Earth's atmosphere. Rocks from Earth's crust have isotope ratios varying by as much as a factor of ten; this is used in geology to investigate the origin of rocks and the composition of the Earth's mantle. The different formation processes of the two stable isotopes of helium produce the differing isotope abundances.
Equal mixtures of liquid 3He and 4He below 0.8 K separate into two immiscible phases due to differences in quantum statistics: 4He atoms are bosons while 3He atoms are fermions. Dilution refrigerators take advantage of the immiscibility of these two isotopes to achieve temperatures of a few millikelvin.
A mix of the two isotopes spontaneously separates into 3He-rich and 4He-rich regions. Phase separation also exists in ultracold gas systems. It has been shown experimentally in a two-component ultracold Fermi gas case. The phase separation can compete with other phenomena as vortex lattice formation or an exotic Fulde–Ferrell–Larkin–Ovchinnikov phase.