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Depolarizing prepulse
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<p>A depolarizing prepulse (DPP) is an electrical stimulus that causes the <a href="/facts/Voltage/EN2po6N2">potential difference</a> measured across a <a href="/facts/Neuron/G7CyTVdH">neuronal</a> <a href="/facts/Cell_membrane/vAXSD0DT">membrane</a> to become more positive or less negative, and precedes another electrical stimulus. DPPs may be of either the voltage or current stimulus variety and have been used to inhibit neural activity, selectively excite neurons, and increase the pain threshold associated with electrocutaneous stimulation. </p>