PCDHB15

Protocadherin beta-15 is a <a href="/facts/Protein/Jxmagu3E">protein</a> that in humans is encoded by the PCDHB15 <a href="/facts/Gene/e1swwPY6">gene</a>.
This gene is a member of the <a href="/facts/Protocadherin/jUNvopUW">protocadherin</a> beta gene cluster, one of three related gene clusters tandemly linked on <a href="/facts/Chromosome_five/wWp5Akno">chromosome five</a>. The gene clusters demonstrate an unusual genomic organization similar to that of <a href="/facts/B-cell/6Y1tgwwp">B-cell</a> and <a href="/facts/T-cell/5z6PQ9UN">T-cell</a> receptor gene clusters. The beta cluster contains 16 genes and 3 <a href="/facts/Pseudogenes/VfbL4L07">pseudogenes</a>, each encoding 6 extracellular cadherin domains and a <a href="/facts/Cytoplasmic/Wa0sE6xf">cytoplasmic</a> tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a <a href="/facts/Homophilic/GFosuGBL">homophilic</a> manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large <a href="/facts/Exon/8KWJtLuN">exon</a>, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral <a href="/facts/Plasma_membrane/vAXSD0DT">plasma membrane</a> proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell <a href="/facts/Neural/CDxRKU2U">neural</a> connections.

PCDHB15 open-in-new

PCDHB15