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Reference.org
Platelet transfusion refractoriness
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<p>Platelet transfusion refractoriness is the repeated failure to achieve the desired level of <a href="/facts/Blood_platelet/I0xrDVGa">blood platelets</a> in a patient following a platelet <a href="/facts/Blood_transfusion/fb0Mk6Dx">transfusion</a>. The cause of refractoriness may be either <a href="/facts/Immune_system/HRCTf1pb">immune</a> or non-immune. Among immune-related refractoriness, antibodies against <a href="/facts/Human_leukocyte_antigen/6QRXe5QI">HLA antigens</a> are the primary cause. Non-immune causes include <a href="/facts/Splenomegaly/hkB1jTdo">splenomegaly</a> (enlargement of the spleen), <a href="/facts/Fever/waVxR2Ac">fever</a>, and sepsis. </p>