Proteinase-activated receptor 1

<p>Proteinase-activated receptor 1 (PAR1) also known as protease-activated receptor 1, coagulation factor II receptor and thrombin receptor is a <a href="/facts/Protein/Jxmagu3E">protein</a> that in humans is encoded by the <i>F2R</i> <a href="/facts/Gene/e1swwPY6">gene</a>. PAR1 is a <a href="/facts/G_protein-coupled_receptor/0arUMkQc">G protein-coupled receptor</a> and one of four <a href="/facts/Protease-activated_receptor/3ooHPl7I">protease-activated receptors</a> involved in the regulation of <a href="/facts/Thrombosis/8Y3wh2UX">thrombotic</a> response. Highly expressed in platelets and endothelial cells, PAR1 plays a key role in mediating the interplay between <a href="/facts/Coagulation/vnfEevM0">coagulation</a> and <a href="/facts/Inflammation/Ura86MIy">inflammation</a>, which is important in the pathogenesis of inflammatory and fibrotic lung diseases. It is also involved both in disruption and maintenance of <a href="/facts/Endothelium/L4ENFVnw">endothelial</a> barrier integrity, through interaction with either <a href="/facts/Thrombin/sU9x3MeH">thrombin</a> or <a href="/facts/Protein_C/sHW1LwrJ">activated protein C</a>, respectively.
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Proteinase-activated receptor 1 open-in-new

Proteinase-activated receptor 1