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Type VII secretion system
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<p>Type VII secretion systems are bacterial <a href="/facts/Secretion_system/VHk9eLAV">secretion systems</a> first observed in the phyla <i><a href="/facts/Actinomycetota/ShmuHEND">Actinomycetota</a></i> and <i><a href="/facts/Bacillota/FxP0p0n8">Bacillota</a></i>. Bacteria use such systems to transport, or secrete, <a href="/facts/Protein/Jxmagu3E">proteins</a> into the environment. The bacterial genus <i><a href="/facts/Mycobacterium/mLn82Axu">Mycobacterium</a></i> uses type VII secretion systems (T7SS) to secrete proteins across their <a href="/facts/Cell_envelope/EHmJsPz3">cell envelope</a>. The first T7SS system discovered was the ESX-1 System. </p><p>T7SS has been studied as a virulence factor associated with the ESX-1 system in <i><a href="/facts/Mycobacterium_tuberculosis/cbRjnhIQ">Mycobacterium tuberculosis</a></i>. These secretion systems are often found in <a href="/facts/Gram-positive_bacteria/H6WYQ17e">gram-positive bacteria</a>. Type VII secretion systems are necessary in <i>Mycobacterium</i> because of their impermeable membrane. The RD1 locus or <a href="/facts/Gene/e1swwPY6">Gene</a> for Type VII secretion can create a lytic effect through ESX-1 transport. </p>