The Cornish Main Line is a railway line in Cornwall and Devon in the United Kingdom. It runs from Penzance to Plymouth, crossing from Cornwall into Devon over the Royal Albert Bridge at Saltash.
It directly serves Truro, St Austell, Bodmin (by a Parkway station) and Liskeard. It forms the backbone for rail services in Cornwall and there are branches off it which serve St Ives, Falmouth, Newquay and Looe. The main line also carries direct trains to and from London, Birmingham, Cardiff, Newcastle and Edinburgh.
It is the southernmost railway line in the United Kingdom and the westernmost in England.