Cryptic unstable transcript

<p>Cryptic unstable transcripts (CUTs) are a subset of <a href="/facts/Non-coding_RNA/aXqyV5so">non-coding RNAs</a> (ncRNAs) that are produced from <a href="/facts/Intergenic/magkGnx7">intergenic</a> and <a href="/facts/Intron/LS6YdBEK">intragenic</a> regions. CUTs were first observed in <i><a href="/facts/S._cerevisiae/sX9MGFrz">S. cerevisiae</a></i> yeast models and are found in most <a href="/facts/Eukaryote/SkwyPLMA">eukaryotes</a>. Some basic characteristics of CUTs include a length of around 200–800 <a href="/facts/Base_pair/xmPpPQ9W">base pairs</a>, a 5' cap, poly-adenylated tail, and rapid degradation due to the combined activity of poly-adenylating polymerases and <a href="/facts/Exosome_complex/h2UWFNnw">exosome complexes</a>. CUT transcription occurs through <a href="/facts/RNA_Polymerase_II/MK2kgybw">RNA Polymerase II</a> and initiates from <a href="/facts/Nucleosome/HX5DR9bn">nucleosome</a>-depleted regions, often in an <a href="/facts/Antisense/hcKgNvy6">antisense</a> orientation. To date, CUTs have a relatively uncharacterized function but have been implicated in a number of putative gene regulation and silencing pathways. Thousands of loci leading to the generation of CUTs have been described in the yeast genome. Additionally, stable uncharacterized transcripts, or SUTs, have also been detected in cells and bear many similarities to CUTs but are not degraded through the same pathways.
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Cryptic unstable transcript open-in-new

Cryptic unstable transcript