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Reference.org
Fas ligand
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<p>Fas ligand (FasL, also known as CD95L or Apo-1L) is a type-II transmembrane protein in the <a href="/facts/Tumor_necrosis_factor/5G0MA0dG">tumor necrosis factor</a> (TNF) superfamily. It binds to the Fas receptor (CD95) to induce <a href="/facts/Apoptosis/8dVzSm4y">apoptosis</a>, and also activates non-apoptotic pathways such as <a href="/facts/NF-%25CE%25BAB/qcpt5vuQ">NF-κB</a> and <a href="/facts/Mitogen-activated_protein_kinase/YdDS5KkU">MAPK</a>. FasL exists in membrane-bound and soluble forms, and is primarily expressed by <a href="/facts/Cytotoxic_T_lymphocytes/e5eRg3XJ">cytotoxic T lymphocytes</a> and <a href="/facts/Natural_killer_cell/A3THWxrJ">natural killer cells</a>. It plays a critical role in immune regulation, immune privilege, cancer, autoimmunity, and transplantation. The expression and function of FasL are tightly regulated to maintain <a href="/facts/Homeostasis/rloTGAHa">immune homeostasis.</a> </p>